北京大学国际癌症研究院

师资队伍

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张宏权北京大学新体制长聘教授

北京大学国际癌症研究院副院长、基础医学院肿瘤、细胞和衰老学科群主任、人体解剖与组织胚胎学系主任、北京大学国际癌症研究院PI、北京大学天然药物及仿生药物国家重点实验室PI，博士生导师，博士后合作导师。目前担任中国抗癌协会肿瘤转移专业委员会主任委员、中国抗癌协会血液病转化医学专业委员会副主任委员、中国生理学会基质生物学专业委员会前任主任委员。

研究方向 :

肿瘤侵袭、转移和耐药的分子细胞生物学机制；组蛋白的表观遗传学修饰及非组蛋白的翻译后修饰调节肿瘤发生发展的分子机制；细胞微环境调控肿瘤进展的分子机制；肿瘤干细胞的重编程机制和抗肿瘤药物的筛选等。

代表性论文： :

1. Jiaqi Jin, Lei Zhang, Xueying Li, Weizhi Xu, Siyuan Yang, Jiagui Song, Wenhao Zhang, Jun Zhan, Jianyuan Luo and Hongquan Zhang. Nucleic Acids Res*. doi.org/10.1093/nar/gkac189, 2022.

2. Yenan Fu, Xi Zhang, Xiao Liu, Peng Wang, Wenhui Chu, Wei Zhao, Yunling Wang, Guangbiao Zhou, Yu Yu and Hongquan Zhang. The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis. Signal Transduction and, Targeted Therapy*. doi:10.1038/s41392-022-00896-1, 2022.

3. Yuhan Jiang, Yixiao Li, Cheng Liu, Lei Zhang, Danyu Lv, Yejing Weng, Zhongyi Cheng, Xiangmei Chen, Jun Zhan, Hongquan Zhang. Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid. Nat Commun. 12(1):5548, 2021.

4. Chu W, Zhang X, Qi L, Fu Y, Wang P, Zhao W, Du J, Zhang J, Zhan J, Wang Y, Zhu WG, Yu Y,

Zhang H*. The EZH2-PHACTR2-AS1-ribosome axis induces genomic instability and promotes

growth and metastasis in breast cancer. Cancer Res. 80(13): 2737-2750, 2020.

5. Song J, Wang T, Chi X, Wei X, Xu S, Yu M, He H, Ma J, Li X, Du J, Sun X, Wang Y, Zhan J* and Zhang H. Kindlin-2 Inhibits the Hippo Signaling Pathway by Promoting Degradation of MOB1. Cell Rep*. 29(11): 3664-3677.e5, 2019.

6. Zhan J, Wang P, Li S, Song J, He H, Wang Y, Liu Z, Wang F, Bai H, Fang W, Du Q, Ye M, Chang Z, Wang J, Zhang H. HOXB13 networking with ABCG1/EZH2/Slug mediates metastasis and confers resistance to cisplatin in lung adenocarcinoma patients. Theranostics*. 9(7):2084-2099, 2019.

7. Wang X, Wei X, Yuan Y, Sun Q, Zhan J, Zhang J, Tang Y, Li F, Ding L, Ye Q, Zhang H. Src-mediated phosphorylation converts FHL1 from tumor suppressor to tumor promoter. J Cell Biol*. 217(4):1335-1351, 2018.

8. Xu W, Wan J, Zhan J, Li X, He H, Shi Z, Zhang H. Global profiling of crotonylation on non-histone proteins. Cell Res.* 27(7):946-949, 2017.

9. Wei X, Wang X, Zhan J, Chen Y, Fang W, Zhang L, Zhang H. Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation. J Cell Biol*. 216(5):1455-1471, 2017.

10.Wan J, Xu W, Zhan J, Ma J, Li X, Xie Y, Wang J, Zhu WG, Luo J, Zhang H. PCAF-mediated acetylation of transcriptional factor HOXB9 suppresses lung adenocarcinoma progression by targeting oncogenic protein JMJD6. Nucleic Acids Res*. 44(22):10662-10675, 2016.