北京大学国际癌症研究院

师资队伍

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谢正伟助理教授

博士生导师，主要应用交叉学科手段，包括人工智能和计算生物学方法，进行衰老和代谢疾病的机制研究和创新药物研发。主要的科研成果包括：1）开发出第一代衰老微流芯片；2）发现端粒酶失活调控早衰的机制；3）发明了代谢分析中的超立方收缩算法；4）发现小檗碱、茶多酚延长寿命的机制；5）开发了基于深度学习和基因指纹的药效预测系统——灵素系统等。以第一作者/通讯作者（含并列）在Nature Biotechnology、Cell、Aging Cell、Bioinformatics、JCIM等杂志发表论文。研究工作曾被《自然》杂志“新闻与视角”栏目长文报道，获评2016中国医学科学研究年度十大进展，2021中国生物信息年度十大进展。主持国家重点研发计划子课题一项，国家自然科学基金面上项目二项，北京市面上项目一项。

研究方向 :

实验室具体的研究方向包括：

1. 开发和完善基于深度学习的，以药效预测为核心的药物设计和优化系统；

2. 研究衰老的分子机制，开发创新延长寿命的药物，发现新的抗衰老靶点；

3. 癌症方面，开发促进免疫治疗应答的药物等；

4. 在代谢疾病、年龄相关疾病方向开展药物研发工作。

代表性文章 :

1. Jie Zhu#, Jingxiang Wang#, Xin Wang#, Mingjing Gao#, Bingbing Guo#, Miaomiao Gao, Jiarui Liu, Yanqiu Yu, Liang Wang, Weikaixin Kong, Yongpan An, Zurui Liu, Xinpei Sun, Zhuo Huang, Hong Zhou,*, Ning Zhang*, Ruimao Zheng*, Zhengwei Xie* Prediction of Drug Efficacy from Transcriptional Profiles with Deep Learning Nature biotechnology 2021,39:1444-1452 doi: 10.1038/s41587-021-00946-z

2. Yiming Wang^#, Weikaixin Kong^#, Liang Wang, Tianyu Zhang, Boyue Huang, Jia Meng, Baoxue Yang, Zhengwei Xie* and Hong Zhou* Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis Int. J. Mol. Sci. 2020(21),7695

3. Weikaixin Kong^#，Miaomiao Gao^#, Yuchen Jin, Zhuo Huang*, Zhengwei Xie*, Prognostic model of patients with liver cancer based on tumor stem cell content and immune process, Aging, 2020 (12) 16, 16555-16578.

4. Weikaixin Kong^#, Xinyu Tu^#, Weiran Huang, Yang Yang, Zhengwei Xie*, Zhuo Huang* Prediction and Optimization of Na_V1.7 Sodium Channel Inhibitors Based on Machine Learning and Simulated Annealing, J. Chem. Inf. Model. May 18, 2020, 60（6）, 2739-2753 (doi:10.1021/acs.jcim.9b01180)

5. Miaomiao Gao^#, Weikaixin Kong^#, Zhuo Huang*, Zhengwei Xie* Identification of Key Genes Related to Lung Squamous Cell Carcinoma Using Bioinformatics Analysis. Int. J. Mol. Sci. 2020, 21(8), 2994 (doi:10.3390/ijms21082994)

6. Boyue Huang^#, Dandan Zhong^#, Jie Zhu, Yongpan An, Miaomiao Gao, Shuai Zhu, Weiwei Dang, Xin Wang, Baoxue Yang* and Zhengwei Xie* Inhibition of Histone Acetyltransferase GCN5 Extends Lifespan in both Yeast and Human Cell Lines. Aging Cell 2020;00:e13129. https://doi.org/10.1111/acel.13129

7. Yao Dang^#, Yongpan An^#, Jinzhao He, Boyue Huang, Jie Zhu, Miaomiao Gao, Shun Zhang, Xin Wang, Baoxue Yang* and Zhengwei Xie* Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression. Aging Cell 2020.19.e13060 https://doi.org/10.1111/acel.13060

8. Zhengwei Xie*, Tianyu Zhang, Qi Ouyang*, Genome-scale fluxes were predicted under the guidance of enzyme abundance using a novel Hyper-Cube Shrink Algorithm, Bioinformatics, 2018.2.1, 34(3): 502~510

9. Zhengwei Xie^*, Kyle Jay^*, Dana L. Smith, Yi Zhang, Zairan Liu, Jiashun Zheng, Ruilin Tian, Hao Li, and Elizabeth Blackburn, Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length Cell 2015 160(5) p928-939 (^*co-first authors)

10. Zhengwei Xie, Yi Zhang, Ke Zou, Onn Brandman, Chunxiong Luo, Qi Ouyang, Hao Li, Molecular Phenotyping of Aging in Single Yeast Cells Using a Novel Microfluidic Device, Aging Cell 2012, (11) p.599~606